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Title:
METHOD FOR PREPARING R-(-)-CARNITINE FROM S-(-)-CHLOROSUCCINIC ACID OR DERIVATIVE THEREOF
Document Type and Number:
Japanese Patent JP2010229157
Kind Code:
A
Abstract:

To provide an improved method for preparing S-(-)-chlorosuccinic acid.

The method for preparing S-(-)-chlorosuccinic acid including a reaction of S-(+)-aspartic acid with sodium nitrate under a hydrochloric acid water condition is characterized in that the S-(+)-aspartic acid is suspended in desalted water in a w/v ratio of 1-0.5 kg/L, concentrated hydrochloric acid is added in a ratio of the S-(+)-aspartic acid to hydrochloric acid of 0.35-0.55 kg/L range in the presence of sodium chloride, the S-(+)-aspartic acid and the sodium chloride are present in a mole ratio of 1:0.3-1:0.5 range, and an improved point is to isolate a reaction product by cooling a reaction mixture to a range of -10°C to -20°C to precipitate the reaction product.


Inventors:
MELLONI PIERO
CERRI ALBERTO
SANTAGOSTINO MARCO
Application Number:
JP2010153891A
Publication Date:
October 14, 2010
Filing Date:
July 06, 2010
Export Citation:
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Assignee:
SIGMA TAU IND FARMACEUTI
International Classes:
C07C51/43; C07D307/60; C07B53/00; C07C51/363; C07C51/377; C07C51/48; C07C51/56; C07C55/32; C07C55/40; C07C69/63; C07C227/08; C07C227/30; C07C227/32; C07C229/22; C07C309/66; A61K31/205; A61P3/06; A61P9/06; A61P9/10; A61P25/08
Other References:
JPN5002008261; JEFFREY A FRICK: SYNTHESIS N7, 199207, P621-623
JPN6012057331; Tetrahedron Vol.41, No.22, p.5241-5260 (1985).
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga