To provide a method for preparing a trifluoromethyl-substituted 2-alkoxyacetophenone derivative which is an important intermediate of drugs and agrochemicals.
The trifluoromethyl-substituted 2-alkoxyacetophenone derivative is obtained by reacting a trifluoromethyl-substituted phenacyl halide with a water-containing lower alcohol solution under acidic or neutral conditions or by brominating a trifluoromethyl-substituted acetophenone with Br2 in the presence of an alkylenediol to give a cyclic acetal of a trifluoromethyl-substituted phenacyl bromide and then reacting the cyclic acetal with a water-containing lower alcohol solution under acidic or neutral conditions. According to this method, the trifluoromethyl-substituted 2-alkoxyacetophenone derivative can be much more simply obtained than before.
KANAI MASATOMI
KURIYAMA KATSU
YASUMOTO MANABU
INOMIYA NORITO
OTSUKA TAKASHI
UEDA KOJI
