Title:
アミコラトプシス・ムジテラネイ細胞を利用した11ベータ-ヒドロキシ-9ベータ,10アルファ-ステロイドの製造方法
Document Type and Number:
Japanese Patent JP2009523434
Kind Code:
A
Abstract:
The invention relates to the use of bacterial strains of the species Amycolatopsis mediterranei for the microbial transformation of 9ß,10a-steroids of general Formula (I) to their corresponding 11ß-hydroxyl analogues, as well as to specific strains of that species. In addition, the present invention relates to the process of transforming 9ß,10a-steroids to their corresponding 11ß-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and to the subsequent isolation of the 11ß-hydroxyl derivatives from the bacterial culture medium. The resultant 11ß-hydroxylated products are useful intermediates for the preparation of novel steroidal compounds with 9ß,10a-confirmation carrying different kind of substituents in the 11ß-position.
Inventors:
Josef Messinger
Heinrich-Hubert Torre
Heinz-Helmer Rache
Michael schmidt
Yuha Hakara
Heinrich-Hubert Torre
Heinz-Helmer Rache
Michael schmidt
Yuha Hakara
Application Number:
JP2008550748A
Publication Date:
June 25, 2009
Filing Date:
January 16, 2007
Export Citation:
Assignee:
Solvay Pharmaceuticals GmbH
International Classes:
C12P33/08; C07J7/00; C07J53/00; C12N1/20; C12R1/01
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Reinhard Einsel
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Reinhard Einsel