Title:
METHOD FOR PRODUCING (1S, 4R)-2-OXA-3-AZABICYCLO[2.2.1]HEPT-5-ENE
Document Type and Number:
Japanese Patent JP2016028038
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for preparing enantiomerically enriched (1 S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene.SOLUTION: There is provided a method for producing an azabicyclo derivative including: reacting cyclopentadiene with protected 1-C-nitroso-β-D-ribofuranosyl halides via hetero-Diels-Alder cycloaddition to prepare a compound of formula (III); and subjecting the resulting compound to hydrolysis and, further, the introduction of an amino-protective group PG1.SELECTED DRAWING: None
Inventors:
MANUELA FRANZEN
CHRISTIAN NOTI
CHRISTIAN NOTI
Application Number:
JP2015160176A
Publication Date:
February 25, 2016
Filing Date:
August 14, 2015
Export Citation:
Assignee:
LONZA AG
International Classes:
C07D261/20; C07H9/04; C07H19/24
Domestic Patent References:
| JPH01203400A | 1989-08-16 | |||
| JPH07267908A | 1995-10-17 |
Other References:
JPN5012017096; Ｊ． ＯＲＧ． ＣＨＥＭ． Ｖｏｌ．６３ Ｎｏ．３, 1998, Ｐ．８８５-８８８
JPN5012017097; ＨＥＬＶＥＴＩＣＡ ＣＨＩＭＩＣＡ ＡＣＴＡ Ｖｏｌ．６７, 1984, Ｐ．１５６８-１５７１
JPN6014033523; Ｔａｒｇｅｔｓ ｉｎ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｓｙｓｔｅｍｓ Ｖｏｌ．１１, 2007, ｐ．３９６-４３０
JPN6014033525; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１１, 1994, ｐ．１１０７-１１１７
JPN6014033527; Ｌｉｅｂｉｇｓ Ａｎｎ． Ｃｈｅｍ． , 1993, ｐ．２６１-２６８
JPN5012017095; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１２, 2000, ｐ．１７１９-１７２６
JPN6014033523; Ｔａｒｇｅｔｓ ｉｎ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｓｙｓｔｅｍｓ Ｖｏｌ．１１, 2007, ｐ．３９６-４３０
JPN6014033525; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１１, 1994, ｐ．１１０７-１１１７
JPN6014033527; Ｌｉｅｂｉｇｓ Ａｎｎ． Ｃｈｅｍ． , 1993, ｐ．２６１-２６８
JPN5012017095; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１２, 2000, ｐ．１７１９-１７２６
JPN5012017096; Ｊ． ＯＲＧ． ＣＨＥＭ． Ｖｏｌ．６３ Ｎｏ．３, 1998, Ｐ．８８５-８８８
JPN5012017097; ＨＥＬＶＥＴＩＣＡ ＣＨＩＭＩＣＡ ＡＣＴＡ Ｖｏｌ．６７, 1984, Ｐ．１５６８-１５７１
JPN5012017097; ＨＥＬＶＥＴＩＣＡ ＣＨＩＭＩＣＡ ＡＣＴＡ Ｖｏｌ．６７, 1984, Ｐ．１５６８-１５７１
JPN6014033523; Ｔａｒｇｅｔｓ ｉｎ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｓｙｓｔｅｍｓ Ｖｏｌ．１１, 2007, ｐ．３９６-４３０
JPN6014033525; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１１, 1994, ｐ．１１０７-１１１７
JPN6014033527; Ｌｉｅｂｉｇｓ Ａｎｎ． Ｃｈｅｍ． , 1993, ｐ．２６１-２６８
JPN5012017095; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１２, 2000, ｐ．１７１９-１７２６
JPN6014033523; Ｔａｒｇｅｔｓ ｉｎ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｓｙｓｔｅｍｓ Ｖｏｌ．１１, 2007, ｐ．３９６-４３０
JPN6014033525; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１１, 1994, ｐ．１１０７-１１１７
JPN6014033527; Ｌｉｅｂｉｇｓ Ａｎｎ． Ｃｈｅｍ． , 1993, ｐ．２６１-２６８
JPN5012017095; ＳＹＮＴＨＥＳＩＳ Ｖｏｌ．１２, 2000, ｐ．１７１９-１７２６
JPN5012017096; Ｊ． ＯＲＧ． ＣＨＥＭ． Ｖｏｌ．６３ Ｎｏ．３, 1998, Ｐ．８８５-８８８
JPN5012017097; ＨＥＬＶＥＴＩＣＡ ＣＨＩＭＩＣＡ ＡＣＴＡ Ｖｏｌ．６７, 1984, Ｐ．１５６８-１５７１
Attorney, Agent or Firm:
Kurata Masatoshi
Nobuhisa Nogawa
Takashi Mine
Naoki Kono
Katsu Sunagawa
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Nobuhisa Nogawa
Takashi Mine
Naoki Kono
Katsu Sunagawa
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi