Title:
METHOD OF PRODUCING (1S,2S,3S,4R)-3-[(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL]-4-GUANIDINO-2-HYDROXY-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES
Document Type and Number:
Japanese Patent JP2014169270
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method of producing a compound that is useful as an anti-influenza medicine, has reduced hygroscopicity, and is controllable in its quality.SOLUTION: In a method of producing a compound (I), a crude composition is heated and dissolved in water, and activated charcoal is added thereto. Then, it is filtrated while being hot, and cooled, and after that, organic solvent is added thereto, or seed crystal is further added thereto. A cooling rate is controlled to precipitate crystal products.
More Like This:
| JP3732873 | ALKYLBENZOYLGUANIDINE DERIVATIVE |
| JPS62148463 | ISOLATION OF DIARYLGUANIDINE |
| WO/2021/044445 | SOLVENT FREE CONTINUOUS PROCESS FOR THE SYNTHESIS OF METFORMIN HYROCHLORIDE |
Inventors:
LI SONG
WU ZHONG
ZHENG ZHIBING
ZHOU XINBO
XIAO JUNHAI
XIE YUNDE
WANG LILI
LI XINGZHOU
ZHAO GUOMING
WANG XIAOKUI
LIU HONGYING
WU ZHONG
ZHENG ZHIBING
ZHOU XINBO
XIAO JUNHAI
XIE YUNDE
WANG LILI
LI XINGZHOU
ZHAO GUOMING
WANG XIAOKUI
LIU HONGYING
Application Number:
JP2013268967A
Publication Date:
September 18, 2014
Filing Date:
December 26, 2013
Export Citation:
Assignee:
INST OF PHARMACOLOGY & TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P L A CHINA
International Classes:
C07C277/08; C07C279/16; A61K31/196; A61P31/16
Domestic Patent References:
| JP2003530306A | 2003-10-14 | |||
| JP2003503384A | 2003-01-28 | |||
| JP2003530306A | 2003-10-14 | |||
| JP2003503384A | 2003-01-28 |
Other References:
JPN6013037276; Ｚｅｉｔｓｃｈｒｉｆｔ ｆｕｅｒ Ｎａｔｕｒｆｏｒｓｃｈｕｎｇ， Ｂ： Ｃｈｅｍｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２ｂ， Ｎｏ．８, 2007, Ｐ．９８３-９８７
JPN6013037272; Ａｎｔｉｖｉｒａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．６９, 2006, Ｐ．３９-４５
JPN6013037276; Ｚｅｉｔｓｃｈｒｉｆｔ ｆｕｅｒ Ｎａｔｕｒｆｏｒｓｃｈｕｎｇ， Ｂ： Ｃｈｅｍｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２ｂ， Ｎｏ．８, 2007, Ｐ．９８３-９８７
JPN6013037272; Ａｎｔｉｖｉｒａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．６９, 2006, Ｐ．３９-４５
JPN6013037272; Ａｎｔｉｖｉｒａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．６９, 2006, Ｐ．３９-４５
JPN6013037276; Ｚｅｉｔｓｃｈｒｉｆｔ ｆｕｅｒ Ｎａｔｕｒｆｏｒｓｃｈｕｎｇ， Ｂ： Ｃｈｅｍｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２ｂ， Ｎｏ．８, 2007, Ｐ．９８３-９８７
JPN6013037272; Ａｎｔｉｖｉｒａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．６９, 2006, Ｐ．３９-４５
Attorney, Agent or Firm:
Hideo Takino
Takao Kawasaki
Toshiaki Tsuda
Fumio Takino
Takao Kawasaki
Toshiaki Tsuda
Fumio Takino
Previous Patent: COSMETIC FAT
Next Patent: AMIDE PERFLUORIDE SALT AND METHOD FOR USING THE SAME AS AN ION-CONDUCTIVE SUBSTANCE
Next Patent: AMIDE PERFLUORIDE SALT AND METHOD FOR USING THE SAME AS AN ION-CONDUCTIVE SUBSTANCE