Title:
METHOD FOR PRODUCING 2-METHYLSPIRO(1,3-OXATHIOLANE-5,3')QUINUCLIDINE SULFATE
Document Type and Number:
Japanese Patent JP2019052093
Kind Code:
A
Abstract:
To provide a method for obtaining 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine sulfate at a high isomer ratio (cis/trans) from 3-hydroxy-3-mercaptomethylquinuclidine without requiring fractionation of isomers or an isomerization step.SOLUTION: There is provided a method for obtaining 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine sulfate which comprises: a step in which a metal halide and an acetaldehyde compound are mixed, followed by further mixing and reacting with 3-hydroxy-3-mercaptomethylquinuclidine to obtain free 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine; and a step in which the free 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine (2) is brought into contact with sulfuric acid at -5 to 45°C to convert into 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine sulfate.SELECTED DRAWING: None
Inventors:
SHIMA HIDEYOSHI
KOMATA YOJI
YAMAMOTO YASUHITO
TAKAMA AKIRA
YONEDA YASUHIRO
KOMATA YOJI
YAMAMOTO YASUHITO
TAKAMA AKIRA
YONEDA YASUHIRO
Application Number:
JP2016016881A
Publication Date:
April 04, 2019
Filing Date:
February 01, 2016
Export Citation:
Assignee:
UBE INDUSTRIES
International Classes:
C07D497/20