プロテアーゼインヒビターとして有用な4-ヒドロキシ-2-オキソ-ピラン誘導体の製法

Japanese Patent JP5266194

B2

Disclosed is a novel process and novel intermediates to prepare [R-(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (XIX) which is a protease inhibitor useful in treating humans infected with the HIV virus.

JP2510839	PREPARATION OF NOVEL N-(ACYLOXY-ALKOXY)CARBONYL DEVITIVES USEFUL AS BIOREVERSIBLE PRODRUG MOIETY FOR PRIMARY AND SECONDARY AMINE FUNCTIONAL GROUPS IN DRUG
JP3157180	REAGENT FOR STEREOSPECIFIC FLUOROMETHYLATION AND PROCESS THEREFOR

James Earl Gage
Robert Sea Kelly
Bradley Di Hewitt

JP2009280318A

August 21, 2013

December 10, 2009

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Pharmacia & Up John Company LRC

C07C205/43; A61K31/366; C07D309/32; A61P31/18; C07B61/00; C07C45/30; C07C47/277; C07C59/48; C07C201/16; C07C205/56; C07D405/04; C07D405/12

WO1995030670A1

Antimicrobial Agents and Chemotherapy,1997年 5月,Vol.41, No.5,p.1058-1063

Mitsuo Tanaka
Hiroshi Yamazaki
Samejima Mutsumi
Tsuyoshi Sato

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