Title:
METHOD FOR PRODUCING 5-BROMO-2-ALKYLBENZOIC ACID
Document Type and Number:
Japanese Patent JP2021127332
Kind Code:
A
Abstract:
To provide a method for producing 5-bromo-2-alkylbenzoic acid, which is useful as a synthetic intermediate of a drug substance such as an antidiabetic, in an industrially inexpensive and efficient manner.SOLUTION: The present disclosure provides a method for producing 5-bromo-2-alkylbenzoic acid by bringing 2-alkylbenzoic acid and bromine into contact with each other, in the presence of sulfuric acid. Particularly if 2-alkylbenzoic acid is 2-methylbenzoic acid, the inventive production method enables efficient production of 5-bromo-2-methylbenzoic acid to be a raw material for producing canagliflozin, one of antidiabetics.SELECTED DRAWING: None
Inventors:
SEKI MASAHIKO
MORI HIROSHI
MORI HIROSHI
Application Number:
JP2020191428A
Publication Date:
September 02, 2021
Filing Date:
November 18, 2020
Export Citation:
Assignee:
TOKUYAMA CORP
International Classes:
C07C51/363; C07C51/43; C07C63/04