METHOD OF PRODUCING ADAPALENE GEL

Title:

METHOD OF PRODUCING ADAPALENE GEL

Document Type and Number:

Japanese Patent JP2014101373

Kind Code:

A

Abstract:

To provide a method of producing adapalene aqueous gels.

A method for producing an adapalene aqueous gel at industrial level comprises the steps of: i) formulating a gelling medium A by mixing water with propylene glycol and then adding a gelling agent to the mixture, in which in the step (i), a gelling agent is added after the propylene glycol; ii) formulating an adapalene medium B by dispersing adapalene in water, in the presence of a surfactant, with the proviso that steps i) and ii) are carried out in parallel or any of step i) or ii) is carried out after the other; iii) adding the adapalene medium B to the gelling medium A; and iv) adjusting the pH by adding neutralizing agent thereto, whereby a gel is formed. All steps in the method are conducted at room temperature.

Inventors:

MAURICE EBEL
RICHARD DUGAT

Application Number:

JP2014021388A

Publication Date:

June 05, 2014

Filing Date:

February 06, 2014

Export Citation:

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Assignee:

GALDERMA RES & DEV

International Classes:

A61K31/192; A61K8/19; A61K8/34; A61K8/36; A61K8/41; A61K8/81; A61K8/86; A61K9/06; A61K47/04; A61K47/10; A61K47/14; A61K47/18; A61K47/32; A61K47/34; A61P17/00; A61P17/10; A61Q19/00

Domestic Patent References:

JP2005513146A	2005-05-12
JP2009508843A	2009-03-05
JP2008501769A	2008-01-24
JP2005526063A	2005-09-02

Foreign References:

US20080075776A1

2008-03-27

Other References:

JPN6013050427; 星登ら: 医薬品添加剤要覧 , 19921125, ｐｐ．７８-９, 株式会社薬業時報社

Attorney, Agent or Firm:

Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro

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