Title:
METHOD FOR PRODUCING ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE
Document Type and Number:
Japanese Patent JP2010222365
Kind Code:
A
Abstract:
To provide various methods for preparing entecavir.
Various intermediates useful in the production of entecavir, and a method for producing these intermediates are provided. A resin adsorption process for the isolation and purification of entecavir and the intermediates thereof is also provided.
Inventors:
PENDRI YADAGIRI R
CHEN CHUNG-PIN H
PATEL SUNIL S
EVANS JEFFREY M
LIANG JING
KRONENTHAL DAVID R
POWERS GERALD L
PRASAD SIVA JOSYULA
BIEN JEFFREY T
SHI ZHONGPING
PATEL RAMESH N
AMIT BANERJEE
CHAN YEUNG Y
RIJHWANI SUSHIL K
SINGH AMBARISH K
WANG XIAO FENG
STOJANOVIC MILAN
DAVID J KUCERA
POLNIASZEK RICHARD
LEWIS CHARLES
THOTTATHIL JOHN
KRISHNAMURTY DHILEEPKUMAR
ZHOU MAOTANG X
VEMISHETTI PURUSHOTHAM
CHEN CHUNG-PIN H
PATEL SUNIL S
EVANS JEFFREY M
LIANG JING
KRONENTHAL DAVID R
POWERS GERALD L
PRASAD SIVA JOSYULA
BIEN JEFFREY T
SHI ZHONGPING
PATEL RAMESH N
AMIT BANERJEE
CHAN YEUNG Y
RIJHWANI SUSHIL K
SINGH AMBARISH K
WANG XIAO FENG
STOJANOVIC MILAN
DAVID J KUCERA
POLNIASZEK RICHARD
LEWIS CHARLES
THOTTATHIL JOHN
KRISHNAMURTY DHILEEPKUMAR
ZHOU MAOTANG X
VEMISHETTI PURUSHOTHAM
Application Number:
JP2010120589A
Publication Date:
October 07, 2010
Filing Date:
May 26, 2010
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
C07D473/18; A61P31/20; C07C67/333; C07C69/757; C07D473/12; C07F7/08; C07F7/18; A61K31/522; C07B61/00
Domestic Patent References:
| JPH04282373A | 1992-10-07 | |||
| JPH01207257A | 1989-08-21 |
Foreign References:
| WO1998009964A1 | 1998-03-12 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka