Title:
芳香族不飽和化合物の製造方法
Document Type and Number:
Japanese Patent JP4269902
Kind Code:
B2
Abstract:
The present invention provides a process for producing an aromatic unsaturated compound of the formula (4)
wherein Ar represents an optionally substituted aromatic group or an optionally substituted heteroaromatic group, and Y represents an electron withdrawing group,
which comprises reacting (a) a compound of the formula (1)
Ar-H(1)
wherein Ar has the same meaning as defined above with (b) a compound of the formula (2)
wherein Y has the same meaning as defined above, and Z represents a lower alkoxy, or
a compound of the formula (3)
wherein Y and Z have the same meanings as defined above, in the presence of (c) an acid or a compound which generates a mineral acid by its hydrolysis.
formula (1) is a compound of the formula (5)
wherein R 1 represents a phenyl optionally substituted by halogen(s), a hydrogen or an alkyl and R 2 represents an alkyl or a phenyl optionally substituted by halogen(s), and
the compound of the formula (4) is a compound of the formula (6)
wherein R 1 and R 2 have the same meanings as defined above. A process for producing fluvastatin which comprises carrying out a process according to claim 1 to obtain a compound of formula (4) which is a compound of formula (7)
and then converting the compound of formula (7) to fluvastatin.
Inventors:
Wang Iki
Tetsuya Ikemoto
Tetsuya Ikemoto
Application Number:
JP2003384566A
Publication Date:
May 27, 2009
Filing Date:
November 14, 2003
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07C67/343; C07B37/04; C07D209/12; C07B61/00; C07C67/32; C07C69/736; C07D209/08; C07D209/10; C07D209/18; C07D209/24
Domestic Patent References:
| JP2001081057A |
Foreign References:
| WO2001092223A1 | ||||
| US5118853 |
Attorney, Agent or Firm:
Toru Nakayama
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