Title:
METHOD FOR PRODUCING CALCIUM SALT OF 1, 5-BENZODIAZEPINE COMPOUND
Document Type and Number:
Japanese Patent JP2019167295
Kind Code:
A
Abstract:
To provide an industrially advantageous method for producing a calcium salt of 1, 5-benzodiazepine compound in an amorphous form.SOLUTION: The present invention provides a method for producing a calcium salt of 1, 5-benzodiazepine compound represented by formula (1), in which a corresponding free carboxylic acid (monomer) is reacted with an alkali metal hydroxide in an isopropyl alcohol, and then an aqueous calcium chloride solution is added thereto for further reaction (Ris tert-butyl ;Ris a cyclohexyl group).SELECTED DRAWING: None
Inventors:
NAKAO TATSU
Application Number:
JP2016132174A
Publication Date:
October 03, 2019
Filing Date:
July 04, 2016
Export Citation:
Assignee:
ZERIA PHARM CO LTD
International Classes:
C07D243/12; A61K31/551; A61P1/00; A61P1/04; A61P29/00; A61P29/02; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto