Title:
カチオン性脂質の製造方法
Document Type and Number:
Japanese Patent JP6583682
Kind Code:
B2
Abstract:
To provide an industrial method for producing a cationic lipid, which does not require a special equipment and by which a cationic lipid of high purity can be efficiently obtained. A cationic lipid represented by formula (1) is mixed with a tetraalkylammonium salt having X - in an organic solvent, and a filtrate obtained by separating a tetraalkylammonium iodide deposited by filtration is concentrated to deposit a tetraalkylammonium iodide, thereby obtaining a cationic lipid represented by formula (2):
Inventors:
Masami Ota
Ken Hamura
Ken Hamura
Application Number:
JP2015239062A
Publication Date:
October 02, 2019
Filing Date:
December 08, 2015
Export Citation:
Assignee:
NOF CORPORATION
International Classes:
C07C213/08; C07C217/28; C07C219/06
Domestic Patent References:
| JP2011509258A | ||||
| JP2002515024A | ||||
| JP5508626A | ||||
| JP2014520085A |
Foreign References:
| WO2008148057A2 | ||||
| WO2007022030A2 |
Other References:
WANG, J et al.,Synthesis and Characterization of Long Chain Alkyl Acyl Carnitine Esters. Potentially Biodegradable Cationic Lipids for use in Gene Delivery,Journal of Medicinal Chemistry,1998年,Vol. 41,pp. 2207-2215
YAN, Y et al.,Smart Self-Assemblies Based on a Surfactant-Encapsulated Photoresponsive Polyoxometalate Complex,Angewandte Chemie, International Edition,2010年,Vol. 49,pp. 9233-9236
YAN, Y et al.,Smart Self-Assemblies Based on a Surfactant-Encapsulated Photoresponsive Polyoxometalate Complex,Angewandte Chemie, International Edition,2010年,Vol. 49,pp. 9233-9236
Attorney, Agent or Firm:
Masumi Hosoda
Juno Aoki
Juno Aoki