Title:
METHOD OF PRODUCING CEFQUINOME PARTICLES
Document Type and Number:
Japanese Patent JP2016047827
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide: cefquinome acid addition salt particles that have physical stability; and suspensions of cefquinome acid addition salt that are more stable, preferably cefquinome sulfate particles.SOLUTION: An acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. Consequently, provided are particles of cefquinome acid addition salt, preferably cefquinome sulfate shown in the following formula, in particle sizes commensurate with micronized material, but with improved stability.SELECTED DRAWING: None
Inventors:
HANS PETER NIEDERMANN
HEIKO BOTHE
HEIKO BOTHE
Application Number:
JP2015200919A
Publication Date:
April 07, 2016
Filing Date:
October 09, 2015
Export Citation:
Assignee:
INTERVET INT BV
International Classes:
C07D501/56; A61K9/16; A61K31/546; A61K47/14; A61P31/04
Domestic Patent References:
| JP2006510607A | 2006-03-30 | |||
| JPH08208662A | 1996-08-13 | |||
| JPH01216995A | 1989-08-30 | |||
| JPH029885A | 1990-01-12 | |||
| JPS63183590A | 1988-07-28 | |||
| JP5859436B2 | 2016-02-10 |
Foreign References:
| WO2003063877A1 | 2003-08-07 | |||
| US20040115260A1 | 2004-06-17 | |||
| CN101050220A | 2007-10-10 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yoshikazu Iwase
Yasufumi Shiroyama
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