Title:
新規チアゾール化合物を用いたセファロスポリン系抗生物質の製造方法
Document Type and Number:
Japanese Patent JP3927808
Kind Code:
B2
Abstract:
The present invention relates to a new, simple, and easy process for preparing cephalosporin antibiotics of the following formula (I), such as ceftazidime and cefixime. The process comprises acylating a 7-amino cephalosporanic acid derivative of the following formula (III) with a crystalline aminothiazole compound of the following formula (II):wherein R1 and R2 are the same or different and independently represent H, a C1-4 alkyl or C3-5 cycloalkyl group, R4 represents acetoxymethyl, methylpyridine, or vinyl, X represents chlorine or bromine, and the acid in the acid addition salt represents an inorganic acid, such as hydrochloric acid, or an organic acid, such as formic acid or acetic acid.
Inventors:
You Dae Chu
Yo Sung Won
Shin Dong Kyun
Lee Munki
Park Misoon
Lee Young Souk
Song Young Souk
Liju Chou
Ausan Mi
Yo Sung Won
Shin Dong Kyun
Lee Munki
Park Misoon
Lee Young Souk
Song Young Souk
Liju Chou
Ausan Mi
Application Number:
JP2001568950A
Publication Date:
June 13, 2007
Filing Date:
March 07, 2001
Export Citation:
Assignee:
Hammi Fine Chemicals Company Limited
International Classes:
C07D501/06; C07D501/00; C07D501/22; C07D501/24; C07D501/34; C07D501/46; C07D513/00
Foreign References:
| WO2001066532A1 | ||||
| WO1998031685A1 |
Attorney, Agent or Firm:
Norio Saeki