Title:
METHOD FOR PRODUCING CEPHEM COMPOUND
Document Type and Number:
Japanese Patent JP2010077115
Kind Code:
A
Abstract:
To provide a method for selectively producing Z isomer of a cephem compound useful as a synthetic intermediate for a cephalosporin antibiotic substance in high yield.
A 3-[2-(4-methylthiazol-5-yl)vinyl]-3-cephem compound (A) expressed by general formula (A) is produced by reacting a 3-[(triphenyl-phosphoranylidene)methyl]-3-cephem compound expressed by general formula (I) with 4-methylthiazol-5-carboxaldehyde expressed by formula (II) at +5 to -50C in a mixed solvent obtained by mixing a chlorinated hydrocarbon with a lower alcohol at a volume ratio (former:latter) of 10:1 or under. In the chemical formulas, R1 and R2 are each aromatic hydrocarbon group.
Inventors:
OHARA NOBUHIKO
WAKUI ATSUSHI
TAKUBO YOSUKE
MATSUMOTO NOBUO
WAKUI ATSUSHI
TAKUBO YOSUKE
MATSUMOTO NOBUO
Application Number:
JP2009189664A
Publication Date:
April 08, 2010
Filing Date:
August 19, 2009
Export Citation:
Assignee:
NIPPON CHEMICAL IND
International Classes:
C07D501/24
Foreign References:
| WO1998058932A1 | 1998-12-30 |
Attorney, Agent or Firm:
Osamu Hatori
Yoshiyuki Matsushima
Yoshiyuki Matsushima