Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PRODUCING CILOSTAZOL
Document Type and Number:
Japanese Patent JP2005350474
Kind Code:
A
Abstract:

To provide an improved method for producing cilostazol and a method for purifying cilostazol by recrystallization.

The method for the production of cilostazol comprises the alkylation of the phenol group of 6-hydroxy-3,4-dihydroxyquinoline (6-HQ) with the δ-carbon of a 5-(4-halobutyl)-1-cyclohexyl-1H-tetrazole. The method is carried out by contacting a solution of the 5-(4-halobutyl)-1-cyclohexyl-1H-tetrazole in a water-immissible organic solvent with a trialkylammonium phase-transfer catalyst in a 6-HQ solution, a water-soluble base and water for a period sufficient for essentially completely converting the tetrazole to cilostazol and separating the produced cilostazol from the two-phase mixture.


Inventors:
MENDELOVICI MARIOARA
FINKELSTEIN NINA
PILARSKI GIDEON
Application Number:
JP2005000181031
Publication Date:
December 22, 2005
Filing Date:
June 21, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
TEVA PHARMA
International Classes:
A61K31/4709; A61P7/02; A61P9/10; C07B61/00; C07D215/227; C07D257/04; C07D401/12; C07D; (IPC1-7): C07D401/12; A61P7/02; A61P9/10
Attorney, Agent or Firm:
石田 敬
鶴田 準一
福本 積
西山 雅也
樋口 外治