METHOD FOR PRODUCING COMPOUND HAVING CF2O BRIDGE

Japanese Patent JP2008303214

A

To provide a method for the preparation of compounds having at least one -CF2-O- bridge in the molecule which starts from readily available starting materials, does not require isolation of intermediates, and gives the products in good yields.

The invention relates to a method for the preparation of compounds containing at least one -CF2-O- bridge in the molecule, in which (a) an acid is added onto at least one ketene dithioketal, (b) the resultant bis(alkylthio)carbenium salt is reacted with at least one compound having at least one hydroxy group in the presence of a base, (c) and subsequently, preferably in situ, the resultant dithioorthoester is subjected to oxidative fluorodesulfurization using a fluorinating agent and an oxidant to give the compound containing at least one -CF2-O- bridge in the molecule.

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KIRSCH PEER
TAUGERBECK ANDREAS
HAHN ALEXANDER

JP2008124884A

December 18, 2008

May 12, 2008

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MERCK PATENT GMBH

C07C41/22; C07B41/04; C07C41/16; C07C41/30; C07C43/225; C07C45/59; C07C45/60; C07C49/467; C07C49/517; C07C49/753; C07C201/12; C07C205/36; C07C205/37; C07C253/30; C07C255/54; C07C323/15; C07C327/36; C07D317/72; C07D319/08; C07D319/14; C07D321/10; C07D339/08; C07D409/06; C07D409/08; C09K19/30; C09K19/34; C09K19/42; C09K19/58

JP2004515535A	2004-05-27
JP2003525286A	2003-08-26

Kiyoji Kuzuwa

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