Title:
カップリング化合物の製造方法
Document Type and Number:
Japanese Patent JP4311069
Kind Code:
B2
Abstract:
There are disclosed a method for producing a cross-coupling compound of formula (3): (Y-)(n-1)R<1>-R<2>-(R<1>)(n'-L) wherein R<1> represents a substituted or unsubstituted, linear, branched, or cyclic hydrocarbon group, and n and n' each represent 1 or 2, provided that when n and n' are the same, both n and n' are not 2, R<2> represents a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted alkenyl group, and Y represents R<2> or X<1>, wherein R<2> is as defined above, and X<1> represents a chlorine, bromine or iodine atom, which method comprises reacting an organic halide of formula (1): n'(R<1>X<1> n), wherein R<1> is as defined above and carbon atoms at the alpha and beta positions relative to X<1> are sp<3> carbon atoms, and X<1>, n and n' are as defined above, with a boron compound of formula (2): mäR<2>(BX<2> 2)n'ü, wherein R<2> and n' are as defined above, X<2> independently represents a hydroxyl group or an alkoxy or aryloxy group, or X<2>2 together form an alkoxy or aryloxy group, and m represents 1 or 2, and m≤n, and the boron atom is bonded with an sp<2> carbon atom of R<2> group, or a boronic acid trimer anhydride thereof, in the presence of a base and a catalyst comprising a nickel compound and a compound of formula (i): wherein R<3> represents a substituted or unsubstituted alkyl group, R<4> represents a hydrogen atom or a substituted or unsubstituted alkyl group, 1 represents an integer of 1 to 3, and p and q each represents an integer of 0 to 2; and a catalyst.
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Inventors:
Itabashi Taimon
Taku Kamikawa
Taku Kamikawa
Application Number:
JP2003111282A
Publication Date:
August 12, 2009
Filing Date:
April 16, 2003
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07C1/32; B01J31/22; C07D307/42; C07B37/04; C07B61/00; C07C11/02; C07C13/19; C07C15/107; C07C17/263; C07C22/08; C07C29/32; C07C33/20; C07C33/46; C07C41/18; C07C41/30; C07C43/164; C07C43/205; C07C43/225; C07C43/23; C07C45/68; C07C49/76; C07C67/293; C07C69/157; C07C253/30; C07C255/33; C07D213/30; C07D233/54; C07D307/79; C07F15/04
Domestic Patent References:
| JP2004091467A | ||||
| JP2003183187A | ||||
| JP2002505663A |
Attorney, Agent or Firm:
Toru Nakayama