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Title:
METHOD FOR PRODUCING CRYSTAL FORM OF N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE
Document Type and Number:
Japanese Patent JP2009280604
Kind Code:
A
Abstract:

To provide a method for producing a crystal form of modification 1 of N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide.

The crystal form of modification 1 is obtained by bringing the crystal form of modification 2 of a compound expressed by formula (I) or a crystal mixture of the crystal form of modification 1 and that of modification 2 to be crystallized by (a) heating in a solid state, (b) preparing as a suspension, subsequently heating the same or (c) dissolving in an organic solvent such as isopropanol or in a mixture of the organic solvent and water, subsequently heating the same.


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Inventors:
FAASCH HOLGER DR
HEDTMANN UDO
WESTENFELDER UWE DR
PAULUS ERICH
Application Number:
JP2009175137A
Publication Date:
December 03, 2009
Filing Date:
July 28, 2009
Export Citation:
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Assignee:
SANOFI AVENTIS DEUTSCHLAND
International Classes:
C07D261/18; A61K31/42; A61P1/00; A61P3/08; A61P11/00; A61P13/02; A61P15/00; A61P17/00; A61P25/00; A61P27/02; A61P27/14; A61P29/00; A61P31/04; A61P35/00; A61P37/00; A61P37/08; B01D9/02; A61P19/02; A61P37/02
Domestic Patent References:
JPS5583767A1980-06-24
JPH05208909A1993-08-20
JPH06329538A1994-11-29
JPH06234635A1994-08-23
JPH06234637A1994-08-23
JPH05506425A1993-09-22
JPH06234636A1994-08-23
JPS527960A1977-01-21
Foreign References:
WO1996033745A11996-10-31
WO1996011682A11996-04-25
Other References:
緒方　章, 化学実験操作法　上巻, JPN6012058431, 1963, pages 381 - 393, ISSN: 0002378674
PAOLA FOSSA: "5-Substituted 4-isoxazolecarboxamides with platelet antiaggregating and other activities", FARMACO, vol. 46(6), JPN6009019572, 1991, pages 789 - 802, ISSN: 0002249108
Attorney, Agent or Firm:
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi



 
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