Title:
カベルゴリンの結晶性I型の製造方法
Document Type and Number:
Japanese Patent JP2005529856
Kind Code:
A
Abstract:
A process for producing crystalline form I of cabergoline, which process comprises the preparation of Form V using heptane as precipitation solvent, and its exclusive conversion into crystalline Form I of cabergoline. The present crystallization process from toluene-heptane solvent system for form V involves "reverse addition" of toluene-cabergoline concentrate to cold heptane.
Inventors:
Shake, Ahmad Wye
Tomasi, Attilio
Tomasi, Attilio
Application Number:
JP2003576438A
Publication Date:
October 06, 2005
Filing Date:
March 10, 2003
Export Citation:
Assignee:
Pharmacia Corporation
Pharmacia, Italy, Societa, Per Azioni
Pharmacia, Italy, Societa, Per Azioni
International Classes:
A61K31/42; A61K31/437; A61P25/00; A61P25/16; C07D261/08; C07D471/04; C07D457/06; (IPC1-7): C07D471/04; A61P25/00; A61P25/16
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri