To provide a method for the organic synthesis of salacinol having inhibiting action on glucotase and a cyclic sulfonium compound analogous to salacinol, and to obtain a cyclic sulfonium compound and its analogous compound produced by the method.
The sulfonium compound such as salacinol can be produced by coupling a compound having a cyclic structure containing four carbon atoms and one sulfur atom such as 1-4-epithio-D-arabinitol synthesized from D-xylitol with a hydroxy-protected erythritol cyclic sulfate ester such as 1,3-O- isopropylidene-D-erythritol synthesized from D-glucose or L-glucose by the ring- opening reaction of the cyclic sulfate ester and deprotecting the hydroxy group of the produced cyclic sulfonium compound having hydroxy group protected with a protecting group such as isopropylidene group.
YUASA HIDEYA
TAKADA JUN
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