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Title:
METHOD FOR PRODUCING EXTERNAL PHARMACEUTICAL COMPOSITION THAT BECOMES FOAMY WHEN IN USE
Document Type and Number:
Japanese Patent JP2018199707
Kind Code:
A
Abstract:
To provide a method for producing external pharmaceutical composition that contains active ingredients, is foamy when in use by a pump-type foamer or the like, and improves foaming property, long-lastingness of foam, foam quality, use feeling, dischargeability, interaction between active ingredient and formulation ingredient, clarity and color of active ingredient, production stability, adverse effect related to safety or the like.SOLUTION: A method for producing an external pharmaceutical composition that is foamy when in use which contains 1) active ingredient, 2) polar solvent, and 3) nonionic surfactant, comprises: a process of heating and stirring a mixture containing 1) to 3); a process of confirming solubilization of the active ingredient by heating and stirring; a process of cooling the mixture in which solubilization of the active ingredient has been confirmed in the confirmation process to room temperature under stirring; and a process of filling the mixture having passed through the cooling process into a non-gas type foamer container, in which the active ingredient is cortisone or the like, the polar solvent is N-alkyl-2-pyrolidone or the like, and the nonionic surfactant is fatty acid monoglyceride or the like.SELECTED DRAWING: None

Inventors:
MASUDA TAKAAKI
KOBAYASHI KOICHI
Application Number:
JP2018160895A
Publication Date:
December 20, 2018
Filing Date:
August 29, 2018
Export Citation:
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Assignee:
POLA PHARMA INC
International Classes:
A61K31/573; A61K9/12; A61K31/661; A61K47/14; A61K47/22; A61K47/34; A61P17/00; A61P17/06; A61P29/00
Attorney, Agent or Firm:
辻田 朋子
村松 大輔