Title:
METHOD OF PRODUCING FINE CHEMICAL MATERIAL BY FERMENTATION
Document Type and Number:
Japanese Patent JP2008259505
Kind Code:
A
Abstract:
To provide a method for accumulating and producing fine chemical materials (e.g., lysine) in a medium of an microorganism or the microorganism by increasing metabolic inflow through pentose phosphate route in the microorganism.
A method for increasing generation of fine chemical materials such as lysine from a microorganism, e.g., a corynebacterium by deregulating a ferment-encoding gene, i.e., fructose-1,6-bisphosphatase, is provided. Further, a new method for producing lysine by regulating carbon inflow directing to oxaloacetic acid (OAA), is also provided. In one a preferable embodiment, a method for producing lysine by using fructose or sucrose as the carbon source is provided.
Inventors:
ZELDER OSKAR
KLOPPROGGE CORINNA
SCHROEDER HARTWIG
HAEFNER STEFAN
KROEGER BURKHARD
KIEFER PATRICK
HEINZLE ELMAR
WITTMANN CHRISTOPH
KLOPPROGGE CORINNA
SCHROEDER HARTWIG
HAEFNER STEFAN
KROEGER BURKHARD
KIEFER PATRICK
HEINZLE ELMAR
WITTMANN CHRISTOPH
Application Number:
JP2008095922A
Publication Date:
October 30, 2008
Filing Date:
April 02, 2008
Export Citation:
Assignee:
BASF SE
International Classes:
C12N1/21; C12N9/16; C12N15/09; C12P13/08
Domestic Patent References:
| JP2002191370A | 2002-07-09 |
Foreign References:
| WO2001000844A2 | 2001-01-04 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita