Title:
ヒドロキシプロピルメチルセルロースアセテートサクシネートの製造方法
Document Type and Number:
Japanese Patent JP7252882
Kind Code:
B2
Abstract:
There is provided a method for producing hydroxypropyl methyl cellulose acetate succinate (HPMCAS), including an esterification step of reacting hydroxypropyl methyl cellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCAS; a precipitation step of precipitating the HPMCAS by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCAS; and a washing and recovery step of washing the HPMCAS in the suspension and recovering the washed HPMCAS. Further, there is provided HPMCAS having yellowness at 20°C of 15.0 or less, as determined in a 2% by mass solution of the HPMCAS in a mixed solvent of dichloromethane, methanol and water in a mass ratio of 44:44:10.
Inventors:
Taishi Kitaguchi
Junichi Matsubara
Mitsuhiro Yoshida
Junichi Matsubara
Mitsuhiro Yoshida
Application Number:
JP2019200033A
Publication Date:
April 05, 2023
Filing Date:
November 01, 2019
Export Citation:
Assignee:
Shin-Etsu Chemical Co., Ltd.
International Classes:
C08B13/00; B01F27/95
Domestic Patent References:
| JP4293901A | ||||
| JP2018076499A |
Foreign References:
| US5008113 |
Attorney, Agent or Firm:
Mitsuo Matsui
Hiroshi Murakami
Yukari Kato
Kawamura English
Hiroshi Murakami
Yukari Kato
Kawamura English