Title:
METHOD FOR PRODUCING INJECTABLE MEDICAMENT PREPARATION
Document Type and Number:
Japanese Patent JP2016047847
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To solve a problem in which only a small amount of medicine arrives at a site of action, and the medicine may cause a side effect on a healthy tissue of the body on the basis of the distribution thereof.SOLUTION: The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective agent which comprises an active agent, a spacer molecule, and at least one protein-binding molecule, and after being added to the body, covalently bonds to the body fluid or tissue constituents via the protein-binding molecule. Thus, the transport form of the active agent that can be cleaved pH-dependently, hydrolytically, or enzymatically in the body under the condition of the active agent released is present.SELECTED DRAWING: None
Inventors:
KRATZ FELIX
Application Number:
JP2015252087A
Publication Date:
April 07, 2016
Filing Date:
December 24, 2015
Export Citation:
Assignee:
KTB TUMORFORSCHUNGS GMBH
International Classes:
A61K47/48; A61K9/08; A61K31/704; A61K45/00; A61K47/42; A61K49/00; A61K51/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/00; A61P43/00
Domestic Patent References:
| JPH09503511A | 1997-04-08 | |||
| JPH10505835A | 1998-06-09 | |||
| JP2002514188A | 2002-05-14 |
Foreign References:
| WO1998017325A2 | 1998-04-30 |
Other References:
KRATZ F, BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. V21 N1, JPN5002009840, 1998, JP, pages 6 - 61
WILLNER,D. ET AL: "(6-Maleimidocaproyl)hydrazone of doxorubicin--a new derivative for the preparation of immunoconjugat", BIOCONJUG CHEM, vol. 4, no. 6, JPN7010003396, 1993, pages 521 - 7, XP002284219, DOI: doi:10.1021/bc00024a015
CRITICAL REVIEWS(TM) IN THERAPEUTIC DRUG CARRIER SYSTEM, vol. 16(3), JPN6017028910, January 1999 (1999-01-01), pages 245 - 288
WILLNER,D. ET AL: "(6-Maleimidocaproyl)hydrazone of doxorubicin--a new derivative for the preparation of immunoconjugat", BIOCONJUG CHEM, vol. 4, no. 6, JPN7010003396, 1993, pages 521 - 7, XP002284219, DOI: doi:10.1021/bc00024a015
CRITICAL REVIEWS(TM) IN THERAPEUTIC DRUG CARRIER SYSTEM, vol. 16(3), JPN6017028910, January 1999 (1999-01-01), pages 245 - 288
Attorney, Agent or Firm:
Einzel Felix-Reinhard
Takuya Kuno
Shuichi Sumiyoshi
Takuya Kuno
Shuichi Sumiyoshi