METHOD FOR PRODUCING ISONITRILE

Title:

METHOD FOR PRODUCING ISONITRILE

Document Type and Number:

Japanese Patent JP2008266164

Kind Code:

A

Abstract:

To provide a method for producing an isonitrile compound by using an alcohol as a raw material without using a metal reagent by using one reactor.

The method for producing the isonitrile includes (A) a step for neutralizing a reaction solution obtained by reacting the alcohol with trimethylsilyl cyanide in the presence of a Broensted acid and containing an N-substituted formamide by adding a first tertiary amine to afford a stirrable reaction mixture, and (B) a step for adding a second tertiary amine and a sulfonic acid halide to the reaction mixture obtained at the foregoing step to provide the isonitrile.

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Inventors:

OKINO TATSUFUMI
KITANO KATSUKAZU

Application Number:

JP2007108567A

Publication Date:

November 06, 2008

Filing Date:

April 17, 2007

Export Citation:

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Assignee:

UNIV HOKKAIDO

International Classes:

C07C291/10

Domestic Patent References:

JP2002370907A	2002-12-24
JP2002370907A	2002-12-24

Other References:

JPN7012002303; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ３９, 1998, １９１１-１９１２
JPN7012002305; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ３７, 1996, ８１２９-８１３２
JPN6012031371; 北野　克和　ｅｔ　ａｌ．: 'イソニトリルのアルコールからの高効率的な合成' 日本化学会第７８春季年会講演予稿集ＩＩ , 200003, ｐ．１４３８
JPN7012002306; Ｄｅｌｐｈｉｎｅ　ＬＡＵＮＡＹ　ｅｔ　ａｌ．: 'Ｓｏｌｉｄ　ｐｈａｓｅ-ｍｅｄｉａｔｅｄ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｉｓｏｎｉｔｒｉｌｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ　ｌｅｔｔｅｒｓ４３, 2002, ｐ．７２０１-７２０３
JPN7012002303; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ３９, 1998, １９１１-１９１２
JPN7012002305; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ３７, 1996, ８１２９-８１３２
JPN6012031371; 北野　克和　ｅｔ　ａｌ．: 'イソニトリルのアルコールからの高効率的な合成' 日本化学会第７８春季年会講演予稿集ＩＩ , 200003, ｐ．１４３８
JPN7012002306; Ｄｅｌｐｈｉｎｅ　ＬＡＵＮＡＹ　ｅｔ　ａｌ．: 'Ｓｏｌｉｄ　ｐｈａｓｅ-ｍｅｄｉａｔｅｄ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｉｓｏｎｉｔｒｉｌｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ　ｌｅｔｔｅｒｓ４３, 2002, ｐ．７２０１-７２０３

Attorney, Agent or Firm:

Koichi Washida

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