Title:
ケト酸およびその誘導体の製造方法
Document Type and Number:
Japanese Patent JP5410422
Kind Code:
B2
Abstract:
A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.
Inventors:
Christoph Copler
Martin hateley
Philip Roth
Barbara Jaeger
Christoph Veckbecker
Klaus Hootmacher
Martin hateley
Philip Roth
Barbara Jaeger
Christoph Veckbecker
Klaus Hootmacher
Application Number:
JP2010515446A
Publication Date:
February 05, 2014
Filing Date:
June 12, 2008
Export Citation:
Assignee:
Evonik Degussa GmbH
International Classes:
C07C51/373; C07C59/185; C07C67/313; C07C69/716; C07C319/18; C07C319/20; C07C321/14; C07D317/32; C07D493/08
Domestic Patent References:
| JP2008526720A | ||||
| JP3058956A | ||||
| JP2002212139A | ||||
| JP55062040A | ||||
| JP58024557A | ||||
| JP2010509928A | ||||
| JP2010506909A |
Attorney, Agent or Firm:
Toshio Yano
Takuya Kuno
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Takuya Kuno
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard