Title:
リポ酸およびジヒドロリポ酸の製造方法
Document Type and Number:
Japanese Patent JP2004509856
Kind Code:
A
Abstract:
Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of or its stereoisomer, where Ms is SO2-R' and R and R' independently of one another is [sic] C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in ethanol and reaction with a complex hydride, (c) the extraction of a protic solution of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents at a pH from 9 to 10, or (d) the extraction of R-dihydrolipoic acid or S-dihydrolipoic acid with organic solvents from a protic solution at a pH of 4 to 5, or a combination of one or more of steps (a) to (d), and processes for the preparation of dihydrolipoic acid and the compound 1,6,8 [lacuna] octanetriol.
Inventors:
Krat, martin, jochen
Nibel, Marx
Pawst, joachim
Nibel, Marx
Pawst, joachim
Application Number:
JP2002515882A
Publication Date:
April 02, 2004
Filing Date:
July 24, 2001
Export Citation:
Assignee:
BASF Aktiengesellschaft
International Classes:
A61K31/20; A61P3/10; C07B53/00; C07C303/38; C07C319/08; C07C319/18; C07C319/28; C07C321/04; C07C323/52; C07D339/04; C07C309/66; (IPC1-7): C07D339/04; C07C319/08; C07C319/28; C07C321/04; C07C323/52
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ishii Teiji
Satoshi Fujita
Ishii Teiji