Title:
METHOD FOR PRODUCING MESO-ZEAXANTHINE
Document Type and Number:
Japanese Patent JP3782051
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for efficiently producing a meso-zeaxanthine in a high yield.
SOLUTION: This method for producing the three-dimensionally homogeneous meso-zeaxanthine comprises (a) resolving a racemic mixture of acetylenediols (R-I) and (S-I) to enantiomers (R-I) and (S-I), (b) each converting the enantiomers (R-I) and (S-I) to 15C phosphonium salts (R-II) and (S-II), (c) reacting R-II or S-II with a 10C dialkylmonoacetal by Wittig reaction to provide 25C acetal R-IV or S-IV, (d) converting R-IV or S-IV to 25C aldehyde R-V or S-V and (e) reacting R-V with a 15C phosphonium salt S-II or reacting S-V with a 15C phosphonium salt R-II.
Inventors:
Hans Georg Ernst
Claus Henrich
Claus Ditrich
Claus Henrich
Claus Ditrich
Application Number:
JP2002268971A
Publication Date:
June 07, 2006
Filing Date:
September 13, 2002
Export Citation:
Assignee:
BASF Aktiengesellschaft
International Classes:
C07C403/24; A61K31/045; C07B61/00; C07C29/74; C07C35/14; C07C35/17; C07C35/18; C07C43/196; C07C47/21; C07C47/225; C07C69/013; C07C69/14; C07C69/145; C07C69/16; C07C69/63; C07C69/65; C07C69/675; C07C403/08; (IPC1-7): C07C403/24; //C07B61/00; C07M7:00
Domestic Patent References:
| JP63264565A | ||||
| JP54130570A | ||||
| JP9169686A |
Other References:
SOUKUP,M. et al.,88. Technical Procedures for the Synthesis of Cartenoids and Related Compounds from 6-Oxo-isophorone,HELVETICA CHIMICA ACTA,1990年,Vol.73,p.868-873
MAYER,H. et al.,SYNTHESIS OF OPTICALLY ACTIVE CAROTENOIDS AND RELATED COMPOUNDS,Pure and Applied Chemistry ,1979年,Vol.51, No.3,p.535-564
KRASNOBAJEW,V. et al.,156.Fermentation of Fragrances: Biotransformation of β-Ionone by Lasiodiplodia theobromae,HELVETICA CHIMICA ACTA,1982年,Vol.65, No.5,p.1590-1601
GREENE,T.W. et al.,PROTECTIVE GROUP IN ORGANIC SYNTHESIS THIRD EDITION,JOHN WILEY and SONS,INC.,1999年,第297~309頁
MAYER,H. et al.,SYNTHESIS OF OPTICALLY ACTIVE CAROTENOIDS AND RELATED COMPOUNDS,Pure and Applied Chemistry ,1979年,Vol.51, No.3,p.535-564
KRASNOBAJEW,V. et al.,156.Fermentation of Fragrances: Biotransformation of β-Ionone by Lasiodiplodia theobromae,HELVETICA CHIMICA ACTA,1982年,Vol.65, No.5,p.1590-1601
GREENE,T.W. et al.,PROTECTIVE GROUP IN ORGANIC SYNTHESIS THIRD EDITION,JOHN WILEY and SONS,INC.,1999年,第297~309頁
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ishii Teiji
Satoshi Fujita
Ishii Teiji
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