METHOD FOR PRODUCING MORPHINE

Title:

METHOD FOR PRODUCING MORPHINE

Document Type and Number:

Japanese Patent JP2010024141

Kind Code:

A

Abstract:

To provide a useful compound for the efficient production method of morphine.

This compound is expressed by general formula (I), (II), or (III) [wherein R1 is a 1-6C alkyl; R2 is an amino-protecting group without substantially being eliminated under a strongly acidic condition; and R3 and R4 are each a 1-6C alkyl]. Preferably the compound is expressed by any of general formulae (I) to (III), wherein R1 is methyl and R2 is a 2,4-dinitrobenzene sulfonic acid group.

Inventors:

FUKUYAMA TORU
YOKOSHIMA SATOSHI
KOIZUMI HIFUMI

Application Number:

JP2008179499A

Publication Date:

February 04, 2010

Filing Date:

July 09, 2008

Export Citation:

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Assignee:

UNIV TOKYO

International Classes:

C07D307/91; C07D307/92; C07D489/02; C07B61/00

Other References:

JPN6013022139; ＴＲＡＵＮＥＲ，Ｄ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　Ｅｎａｎｔｉｏｍｅｒｉｃａｌｌｙ　Ｐｕｒｅ　Ｍｏｒｐｈｉｎｅ　Ａｌｋａｌｏｉｄｓ：　Ｔｈｅ　Ｈｙｄｒｏｐｈｅｎａｎｔｈｒｅｎｅ　Ｒｏｕｔｅ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　ＣｈｅｍｉｓｔｒｙＶｏｌ．６３，　Ｎｏ．１７, 1998, ｐ．５９０８-５９１８
JPN6013022140; ＴＯＴＨ，Ｊ．Ｅ．　ｅｔ　ａｌ: 'Ｆｏｒｍａｔｉｏｎ　ｏｆ　ｔｈｅ　ｎｅｏｐｉｎｏｎｅ／ｃｏｄｅｉｎｏｎｅ　ｒｉｎｇ　ｓｙｓｔｅｍ　ｖｉａ　ｉｎｔｒａｍｏｌｅｃｕｌａｒ　１，６-ａｄｄｉｔｉｏｎ　ｏｆ　ａｎ　ａｍｉｎｏ　ｍｏｉｅｔｙ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　ＣｈｅｍｉｓｔｒｙＶｏｌ．５１，　Ｎｏ．１３, 1986, ｐ．２５９４-２５９６

Attorney, Agent or Firm:

Patent Service Corporation Patent Office Sykes

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