Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE 3-AMINO-3-(2- HYDROXYARYL)PROPIONIC ACID AND ITS ESTER
Document Type and Number:
Japanese Patent JP2002308841
Kind Code:
A
Abstract:
To provide a method for simply and efficiently producing optically active 3-amino-(2-hydroxyaryl)propionic acids and their esters which are useful as pharmaceutical intermediates, particularly as the inhibitors of integrin reptors.
The optically active 3-amino-(2-hydroxyaryl)propionic acids and their esters are produced from a 3-(2-hydroxyaryl)-3-oxopropionic acid or its ester and an optically active 2-amino-2-substituted arylphenylethane compound by four steps of (a) imination or enamination, (b) stereoselective reduction, (c) elimination of the substituent on nitrogen, and (d) hydrolysis or transesterification.
Inventors:
TAKEDA TOSHIHIRO
MAEHARA KATSUHARU
UEDA NAOHIRO
OGURO KAZUMI
YAO TAKASHI
INOUE KENJI
UEDA YASUYOSHI
MAEHARA KATSUHARU
UEDA NAOHIRO
OGURO KAZUMI
YAO TAKASHI
INOUE KENJI
UEDA YASUYOSHI
Application Number:
JP2001115254A
Publication Date:
October 23, 2002
Filing Date:
April 13, 2001
Export Citation:
Assignee:
KANEGAFUCHI CHEMICAL IND
International Classes:
C07C227/18; C07B61/00; C07C229/34; C07C303/32; C07C309/30; (IPC1-7): C07C227/18; C07B61/00; C07C229/34; C07C303/32; C07C309/30