To provide a method for efficiently producing an optically active alcohol compound.
A asymmetric ketone compound of general formula (R1 and R2 are different and each a substitutable aryl, a substitutable alkyl, a substitutable cycloalkyl, a substitutable alkenyl, a substitutable cycloalkenyl or R1 and R2 together form an asymmetric cyclic structure) is reduced with hydroborane in the presence of a chiral β-aminoalcohol compound of general formula (II) (R3 is an alkyl, a cycloalkyl or a substitutable aryl; R4 and R5 are each H, an alkyl, a cycloalkyl or a substitutable aryl; R6 is H, an alkyl or a cycloalkyl; R3 forms a cyclic structure together with R4, R5 or R6; carbon atom with *1 (R) configuration or (S) configuration) and a trialkoxyaluminum of general formula (III) (R7 is an alkyl) to give an optically active alcohol compound of general formula (IV) (R1a and R2a are the same as R1 and R2 or groups obtained by reducing R1 and R2; carbon atom with *2 is an (R) configuration or an (S) configuration).
YANAGI TAKASHI
KIKUCHI TAKESHI
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