METHOD FOR PRODUCING OPTICALLY ACTIVE ALPHA-FLUOROCARBOXYLIC ACID ESTER

Title:

METHOD FOR PRODUCING OPTICALLY ACTIVE ALPHA-FLUOROCARBOXYLIC ACID ESTER

Document Type and Number:

Japanese Patent JP2008201770

Kind Code:

A

Abstract:

To provide a production method suitable for the mass production of an optically active -fluorocarboxylic acid ester which is an important intermediate for pharmaceuticals/agrochemicals and optical materials.

The optically active -fluorocarboxylic acid ester is produced by reacting an optically active -hyldroxycarboxylic acid ester with sulfuryl fluoride (SO2F2), trifluoromethane sulfonyl fluoride (CF3SO2F), or nonafluorobutane sulfonyl fluoride (C4F9SO2F) in the presence of an organic base and in the absence of a reaction solvent. More desirably, the optically active -fluorocarboxylic acid ester of a still higher purity can be produced by distillatively purifying the ester after the addition of an acid. According to this method, the optically active -fluorocarboxylic acid ester can be advantageously produced on a large scale.

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Inventors:

ISHII AKIHISA
TSURUTA HIDEYUKI
MORINO YUZURU
TAKAHASHI MIKIHIRO

Application Number:

JP2007212495A

Publication Date:

September 04, 2008

Filing Date:

August 16, 2007

Export Citation:

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Assignee:

CENTRAL GLASS CO LTD

International Classes:

C07C67/307; C07C69/63; C07B55/00; C07B61/00

Domestic Patent References:

JP2006290870A	2006-10-26
JP2006083163A	2006-03-30
JP2002530356A	2002-09-17

Attorney, Agent or Firm:

Yoshiaki Hanada

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