To provide a method for producing an optically active α-amino acids important as a production intermediate for various industrial chemicals, agrochemicals, and pharmaceuticals in high quality and at low cost.
In the method, a resolution agent which stereoselectively forms a salt having low solubility with either one of optical isomer of a D-form or L-form is reacted to a mixture of an L-α-amino acid with a D-α-amino acid, either one of the D-form or L-form α-amino acid is separated as a solid of a diastereomeric salt, living cells of a microorganism having amino acid racemization activity or a treated product of the same is acted to the resultant α-amino acid mixture rich in the residual L-form or D-form to reduce optical purity and the resultant product is repeatedly subjected to the stereoselective resolution by diastereomeric salt formation.
TANAKA TOMOSUKE
| JPH0570415A | 1993-03-23 | |||
| JPS6169748A | 1986-04-10 | |||
| JP2006169158A | 2006-06-29 | |||
| JPS6342692A | 1988-02-23 | |||
| JPS62205781A | 1987-09-10 | |||
| JP2004057014A | 2004-02-26 |
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JPN7014002474; Ｋｕｒｏｄａ，Ｍ． ｅｔ ａｌ: ４-ａｍｉｎｏｂｕｔｙｒａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ［Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ｓａｐｒｏｐｈｙｔｉｃｕｓ ｓｕｂｓｐ．ｓａｐｒｏｐｈｙｔｉｃｕｓ ＡＴＣＣ １５３０５］ , 2005, ＮＣＢＩ
JPN7014002475; Ｍｏｒｉｔａ，Ｈ． ｅｔ ａｌ: ４-ａｍｉｎｏｂｕｔｙｒａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ［Ｌａｃｔｏｂａｃｉｌｌｕｓ ｆｅｒｍｅｎｔｕｍ ＩＦＯ ３９５６］ , 2008
JPN7014002476; Ｚｈａｎｇ，Ｙ．Ｑ． ｅｔ ａｌ: ４-ａｍｉｎｏｂｕｔｙｒａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ［Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ｅｐｉｄｅｒｍｉｄｉｓ ＡＴＣＣ １２２２８］ , 2003
JPN7014002477; Ｋａｗａｒａｂａｙａｓｉ，Ｙ． ｅｔ ａｌ: ４-ａｍｉｎｏｂｕｔｙｒａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ［Ｐｙｒｏｃｏｃｃｕｓ ｈｏｒｉｋｏｓｈｉｉ ＯＴ３］ , 1998
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