Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE ERYTHRO-3-AMINO-2- HYDROXY-4-PHENYLBUTYRIC ACID OR INTERMEDIATE THEREOF
Document Type and Number:
Japanese Patent JP2003137856
Kind Code:
A
Abstract:

To provide a method for efficiently and safely producing (2S, 3S)-3- amino-2-hydroxy-4-phenylbutyric acid with improved erythroselectivity via a silyl derivative as a new compound, and to provide a method for efficiently and safely producing its intermediate.

The (2S, 3S)-(3-protected amino)-2-hydroxy-4-phenylbutyric acid is produced by the following procedure: the new compound (2S, 3S)-3-(N- protected amino)-1-(alkoxydialkylsilanyl)-4-phenylbutan-2-ol making the erythroselectivity determinant is used, and the terminal hydroxy group thereof is converted to a carboxy group without changing the configuration of the hydroxy group formed, using 2,2,6,6-tetramethylpiperidine-1-oxyl, a chlorite and a hypochlorite.


Inventors:
IKENAKA MASAYA
MATSUMOTO ATSUSHI
Application Number:
JP2001330408A
Publication Date:
May 14, 2003
Filing Date:
October 29, 2001
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NAGASE & CO LTD
International Classes:
C07C269/06; C07B61/00; C07C213/00; C07C213/08; C07C215/34; C07C269/04; C07C271/16; C07C271/22; C07F7/18; (IPC1-7): C07C269/06; C07C213/00; C07C213/08; C07C215/34; C07C269/04; C07C271/16; C07C271/22; C07F7/18