Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE ETHYL 1-AMINO-2-ETHENYLCYCLOPROPANE-1-CARBOXYLATE OR ACID ADDITION SALT THEREOF, AND INTERMEDIATE USED FOR THE PRODUCTION METHOD
Document Type and Number:
Japanese Patent JP2011046613
Kind Code:
A
Abstract:
To provide a method for producing optically active ethyl 1-amino-2-ethenylcyclopropane-1-carboxylate.
The method for producing optically active ethyl 1-amino-2-ethenylcyclopropane-1-carboxylate represented by formula (3) or an enantiomer thereof, or an acid addition salt thereof, comprises a process for bringing a mixture comprising (1R, 2S) and (1S, 2R) isomers of ethyl 1-amino-2-ethenylcyclopropane-1-carboxylate into contact with a specific optically active tartranilic acid compound to produce a diastereomer salt mixture, a process for separating one of the diastereomer salts from the other, and a process for bringing the separated one diastereomer salt into contact with an acid or a base to hydrolyze the separated one diastereomer salt.
Inventors:
YASUOKA JUNICHI
AIKAWA TOSHIAKI
IKEMOTO TETSUYA
AIKAWA TOSHIAKI
IKEMOTO TETSUYA
Application Number:
JP2009193914A
Publication Date:
March 10, 2011
Filing Date:
August 25, 2009
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
C07C227/34; C07B57/00; C07C229/48; C07C235/16
Domestic Patent References:
JP2002522557A | 2002-07-23 | |||
JP2001089431A | 2001-04-03 | |||
JPH10218847A | 1998-08-18 | |||
JP2001097933A | 2001-04-10 | |||
JP2004051604A | 2004-02-19 | |||
JP2001131148A | 2001-05-15 | |||
JP2006282605A | 2006-10-19 | |||
JP2006282606A | 2006-10-19 | |||
JP2006282607A | 2006-10-19 |
Other References:
JPN6010052827; Pierre L. B. et al.: 'Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Interme' J. Org. Chem. 70(15), 2005, p.5869-5879
Attorney, Agent or Firm:
Toru Nakayama
Toru Sakamoto
Toru Sakamoto