METHOD OF PRODUCING OPTICALLY ACTIVE α-SUBSTITUTED PROLINES

Title:

METHOD OF PRODUCING OPTICALLY ACTIVE α-SUBSTITUTED PROLINES

Document Type and Number:

Japanese Patent JP2014101330

Kind Code:

A

Abstract:

To provide an industrial method practically suitable for producing an optically active α-substituted prolines with short process and mild conditions.

A method of producing an optically active α-substituted prolines (6) includes (d) a step of obtaining an optically active N, α-substituted prolines (5) by hydrolysis of an optically active N, α-substituted proline amides (4), and (e) a step of obtaining an optically active α-substituted prolines (6) by eliminating the optically active N, and a protective group R² of the α-substituted prolines (5).

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Inventors:

NAGAHAMA MASAKI
SEKI MASAHIKO
UEHARA HISATOSHI
SAITO YASUYO

Application Number:

JP2012255641A

Publication Date:

June 05, 2014

Filing Date:

November 21, 2012

Export Citation:

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Assignee:

API CORP

International Classes:

C07D207/16

Foreign References:

WO2012165023A1	2012-12-06
WO2012165023A1	2012-12-06

Other References:

JPN6016007897; Ｄｅ　ＰＯＬＩ，　Ｍａｔｔｅｏ，　ｅｔ　ａｌ．: Ｃｈｅｍ．　Ｅｕｒ．　Ｊ．１５, 2009, ８０１５-８０２５
JPN6016007899; ＳＨＡＴＺＭＩＬＬＥＲ，　Ｓｈｉｍｏｎ，　ｅｔ　ａｌ．: Ｌｉｅｂｉｇｓ　Ａｎｎ．　Ｃｈｅｍ． , 1991, ３７５-３７９
JPN6016007900; ＧＲＹＧＯＲＥＮＫＯ，　Ｏｌｅｋｓａｎｄｒ　Ｏ．，　ｅｔ　ａｌ．: Ｔｅｔｒａｈｅｄｒｏｎ：　Ａｓｙｍｍｅｔｒｙ１８, 2007, ２９０-２９７
JPN6016007901; ＩＳＡＡＣＳＯＮ，　Ｊｅｒｒｙ，　ｅｔ　ａｌ．: Ｏｒｇａｎｉｃ　Ｌｅｔｔｅｒｓ１０（７）, 2008, １４６１-１４６３
JPN6016007897; Ｄｅ　ＰＯＬＩ，　Ｍａｔｔｅｏ，　ｅｔ　ａｌ．: Ｃｈｅｍ．　Ｅｕｒ．　Ｊ．１５, 2009, ８０１５-８０２５
JPN6016007899; ＳＨＡＴＺＭＩＬＬＥＲ，　Ｓｈｉｍｏｎ，　ｅｔ　ａｌ．: Ｌｉｅｂｉｇｓ　Ａｎｎ．　Ｃｈｅｍ． , 1991, ３７５-３７９
JPN6016007900; ＧＲＹＧＯＲＥＮＫＯ，　Ｏｌｅｋｓａｎｄｒ　Ｏ．，　ｅｔ　ａｌ．: Ｔｅｔｒａｈｅｄｒｏｎ：　Ａｓｙｍｍｅｔｒｙ１８, 2007, ２９０-２９７
JPN6016007901; ＩＳＡＡＣＳＯＮ，　Ｊｅｒｒｙ，　ｅｔ　ａｌ．: Ｏｒｇａｎｉｃ　Ｌｅｔｔｅｒｓ１０（７）, 2008, １４６１-１４６３

Attorney, Agent or Firm:

Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma

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