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Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE TETRAHYDROFURAN-2-CARBOXYLIC ACID
Document Type and Number:
Japanese Patent JP2014172856
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To produce a high-purity optically active tetrahydrofuran-2-carboxylic acid having optical activity efficiently with high productivity.SOLUTION: There is provided a method for producing a high-purity (R)- or (S)-tetrahydrofuran-2-carboxylic acid, the method comprising: (a first step) in which a salt of (R)- or (S)-tetrahydrofuran-2-carboxylic acid and an aromatic amine are subjected to salt exchange with an inorganic metal base in water and then the aromatic amine is removed with a hydrocarbon-based solvent and/or an ether-based solvent to obtain a water layer containing (R)- or (S)-tetrahydrofuran-2-carboxylic acid; (a second step) in which an inorganic acid is added to the water phase obtained in the first step to change the pH to acid and then extracted with tetrahydrofuran; and (a third step) in which the extract obtained in the second step is concentrated and distilled.

Inventors:
HIRAGA HISAFUMI
MORIMOTO MASAO
NISHIMURA TOMOAKI
Application Number:
JP2013046400A
Publication Date:
September 22, 2014
Filing Date:
March 08, 2013
Export Citation:
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Assignee:
TORAY FINE CHEMICALS CO LTD
International Classes:
C07D307/24; C07B57/00
Domestic Patent References:
JPH01216983A1989-08-30
JPH037272A1991-01-14
JPH0971576A1997-03-18
JPH0859517A1996-03-05
JP2002171994A2002-06-18
JPH09143101A1997-06-03
Foreign References:
CN101429180A2009-05-13
Attorney, Agent or Firm:
Tomonori Iwami