METHOD FOR PRODUCING ORAL FORMULATION WHICH DIRECTLY DISSOLVES IN ORAL CAVITY AND RELEASES ACTIVE SUBSTANCE

Japanese Patent JP2014159424

A

PROBLEM TO BE SOLVED: To provide a method for producing an oral formulation which directly dissolves in oral cavity and releases an active substance, and to provide a powder containing an active substance and the use thereof.SOLUTION: (a) An anionic pharmaceutical active substance is powerfully mixed with (b) a copolymer which consists of another (meta-) acrylate monomer having C-C-ester, which produced by radical polymerization of acrylic or methacrylic acids, and a functional third amino group, and (c) C-C-carboxylic acid of 5-50 mass% to (b) in a molten material; the mixture is solidified and ground into a powder which contains an active substance having an average particle diameter of 200 μm or less; and the powder is embedded into a water-soluble matrix consisting of a pharmaceutically common adjuvant. But in that time, an emulsifier having a HLB value of at least 14 should not be contained more than 3 mass% to the copolymer.

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PETEREIT HANS-ULRICH
MEIER CHRISTIAN
ANDREAS GRYCZKE

JP2014039093A

September 04, 2014

February 28, 2014

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EVONIK ROEHM GMBH

A61K9/00; A61K9/14; A61K9/16; A61K9/19; A61K9/20; A61K31/192; A61K45/00; A61K47/12; A61K47/32; A61P29/00; A61P31/04

アインゼル Felix-Reinhardt
Bernard Masako
Takuya Kuno

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