Title:
β-フェニルイソセリン誘導体の製造法
Document Type and Number:
Japanese Patent JP3633619
Kind Code:
B2
Abstract:
PCT No. PCT/FR94/00339 Sec. 371 Date Sep. 28, 1995 Sec. 102(e) Date Sep. 28, 1995 PCT Filed Mar. 25, 1994 PCT Pub. No. WO94/22813 PCT Pub. Date Oct. 13, 1994Method for the preparation of beta -phenylisoserine derivatives of general formula (I) involving the action of an anhydride and hydrogen with a product of general formula (II). The products of general formula (I) are especially useful in the preparation of taxoids having outstanding antitumour properties. In general formulae (I) and (II), Ar is an aryl radical, Ph is a phenyl radical or an optionally substituted alpha or beta -naphtyl, R is a hydrogen atom or an alkyl radical optionally substituted by a phenyl radical and R1 is an optionally substituted phenyl radical or a R2-O radical wherein R2 is an alkyl, alkenyl, cycloalkyl, phenyl or heterocyclyl. (I) (II)
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Inventors:
Erik, Dayday
Leon, patrick
Leon, patrick
Application Number:
JP52174294A
Publication Date:
March 30, 2005
Filing Date:
March 25, 1994
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
C07C231/02; C07C231/18; C07C233/76; C07C233/87; C07C269/04; C07C271/22; C07D305/14; (IPC1-7): C07C231/18; C07C233/87; C07C269/04; C07C271/22; C07D305/14
Domestic Patent References:
| JP383956A |
Attorney, Agent or Firm:
Heikichi Odashima