To produce a high-purity porphyrin compound in high yield.
The method for producing porthyrin compound comprises reducing a pyrrole-2-carboxylic acid ester derivative, refining a 2-hydroxymethylpyrrole derivative from a reaction product containing the 2-hydroxymethylpyrrole derivative and carrying out cyclodehydration and oxidation of the 2-hydroxymethylpyrrole derivative. In the production method, a 2-methylpyrrole derivative of by-product contained in the 2-hydroxymethylpyrrole derivative produced in a reduction process of a pyrrole-2-carboxylic acid ester derivative is removed. As a result, selectivity obtained when selecting a polyphyrinogen derivative by cyclodehydration of the 2-hydroxymethylpyrrole derivative is increased and yield of the porphyrin compound of the final product can be increased thereby.
SAKAI YOSHIMASA
KIYOKU KEIHEI
ARAMAKI SHINJI
URATA HISAO
JPS63238078A | 1988-10-04 | |||
JP2004323376A | 2004-11-18 | |||
JP2004006750A | 2004-01-08 |