Title:
プリン誘導体の製造方法
Document Type and Number:
Japanese Patent JP4459439
Kind Code:
B2
Abstract:
The invention provides a method of rearranging a compound of formula (I), wherein R and R' are selected independently from hydrogen and C1-12alkyl; and R1 and R2 are selected independently from hydrogen, hydroxy, halo, C1-12alkyl- or aryl carbonate, amino, mono- or di-C1-12alkylamino, C1-12alkyl or arylamido, C1-12alkyl- or arylcarbonyl, C1-12alkyl- or arylcarboxy, C1-12alkyl- or arylcarbamoyl, C1-12alkyl, C2-12alkenyl, C2-12alkynyl, aryl, heteroaryl, C1-12alkoxy, aryloxy, azido, C1-12alkyl- or arylthio, C1-12alkyl- or arylsulfonyl, C1-12alkyl- or arylsilyl, C1-12alkyl- or arylphosphoryl, and phosphato; to form a compound of formula (II), wherein R, R', R1 and R2 are as defined for formula (I); said method comprising treating the compound of formula (I) with a palladium (0) catalyst and a (diphenylphosphino)nC1-6 alkane, wherein n is an integer of 1-6. The invention also provides methods of R making penciclovir and famciclovir using this rearrangement reaction.
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Inventors:
Graham Richard Gean
Andrew Colin Share
Andrew Colin Share
Application Number:
JP2000542325A
Publication Date:
April 28, 2010
Filing Date:
March 30, 1999
Export Citation:
Assignee:
NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.
International Classes:
C07D473/32; A61K31/52; A61K31/522; A61P31/12; C07D473/18; C07D473/40
Domestic Patent References:
| JP9512000A |
Other References:
Gundersen,L.L.,et al,Acta Chemica Scandinavica,1992年,Vol.46,pages 761-771
B.M.CHOUDARY ET AL,NUCLEOSIDERS AND NUCLEOTIDES,1996年 5月 1日,V15 N5,P981-994
Rao, T.et al,Journal of Heterocyclic Chemistry ,1995年,Vol.32,pages 1043-1049
B.M.CHOUDARY ET AL,NUCLEOSIDERS AND NUCLEOTIDES,1996年 5月 1日,V15 N5,P981-994
Rao, T.et al,Journal of Heterocyclic Chemistry ,1995年,Vol.32,pages 1043-1049
Attorney, Agent or Firm:
Aoyama Aoi
Kazuaki Kojima
Mitsutaka Iwasaki
Kazuaki Kojima
Mitsutaka Iwasaki