Title:
METHOD FOR PRODUCING QUINAZOLINE RHO-KINASE INHIBITOR AND INTERMEDIATE THEREOF
Document Type and Number:
Japanese Patent JP2011021027
Kind Code:
A
Abstract:
To provide a method for producing a quinazoline compound useful as an Rho-kinase inhibitor and its intermediate.
There is provided a method for producing a compound of e.g. the formula by introducing an arylamino group to a quinazoline compound used as an intermediate. The Rho-kinase inhibitor is useful for inhibiting tumor growth, treating erectile dysfunction, etc.
Inventors:
BANKSTON DONALD
NAGARATHNAM DHANAPHALAN
ASGARI DAVOUD
SHAO JIANXING
LIU XIAO-GAO
KHIRE UDAY
WANG CHUNGUANG
HART BARRY
BOYER STEPHEN
WEBER OLAF
LYNCH MARK
NAGARATHNAM DHANAPHALAN
ASGARI DAVOUD
SHAO JIANXING
LIU XIAO-GAO
KHIRE UDAY
WANG CHUNGUANG
HART BARRY
BOYER STEPHEN
WEBER OLAF
LYNCH MARK
Application Number:
JP2010216425A
Publication Date:
February 03, 2011
Filing Date:
September 28, 2010
Export Citation:
Assignee:
BAYER PHARMACEUTICALS CORP
International Classes:
C07D401/14; C07D239/86; C07D239/91; C07D239/93; C07D307/79; C07D403/12; C07D403/14; C07D405/04; C07D405/14; A61K31/517; A61P7/02; A61P9/10; A61P9/12; A61P11/06; A61P15/10; A61P19/10; A61P27/06; A61P35/00; A61P35/04; A61P43/00
Domestic Patent References:
| JP2002523502A | 2002-07-30 | |||
| JPH11508906A | 1999-08-03 |
Foreign References:
| WO2002024667A1 | 2002-03-28 |
Other References:
JPN6012051719; Ｊ． Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍ． ｖｏｌ．１６, 1979, ｐ．７１１-７１５
Attorney, Agent or Firm:
Akaoka Michio
Kazuo Akaoka
Kazuo Akaoka
Previous Patent: JP2011021026
Next Patent: ARYL-SUBSTITUTED PYRAZOLE, IMIDAZOLE, OXAZOLE, THIAZOLE, AND PYRROLE, AND USE THEREOF
Next Patent: ARYL-SUBSTITUTED PYRAZOLE, IMIDAZOLE, OXAZOLE, THIAZOLE, AND PYRROLE, AND USE THEREOF