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Title:
METHOD FOR PRODUCING RADIOACTIVE DIAGNOSTIC IMAGING AGENT, AND RADIOLYSIS CONTROL METHOD
Document Type and Number:
Japanese Patent JP2012229256
Kind Code:
A
Abstract:

To provide a radioactive diagnostic imaging agent comprising a radioactive halogen-labeled compound having higher stability as an active ingredient, by controlling radiolysis of the active ingredient.

A biologically acceptable saccharide or sugar alcohol is added to the radioactive diagnostic imaging agent in an amount effective for control of radiolysis. The amount of the saccharide or sugar alcohol to be added is preferably 10 (mmol/L)/GBq/mL or more, more preferably 50 (mmol/L)/GBq/mL or more. The saccharide is preferably selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, erythrulose, ribulose, xylulose, psicose, fructose, sorbose and tagatose. The sugar alcohol is preferably selected from the group consisting of erythritol, xylitol, sorbitol and mannitol.


Inventors:
SHIMADA RYUSUKE
NAKATANI AKIRA
TAKAHASHI HIROYOSHI
Application Number:
JP2012159089A
Publication Date:
November 22, 2012
Filing Date:
July 17, 2012
Export Citation:
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Assignee:
NIHON MEDIPHYSICS CO LTD
International Classes:
A61K51/00; A61K47/10; A61K47/26
Domestic Patent References:
JPH09176179A1997-07-08
JPH05271102A1993-10-19
JPH06510539A1994-11-24
JPH07503468A1995-04-13
JPH04505455A1992-09-24
JPH10147542A1998-06-02
Foreign References:
WO1993002652A21993-02-18
US4857299A1989-08-15
Attorney, Agent or Firm:
Masatake Ide