Title:
METHOD FOR PRODUCING (S)-2-HYDROXYPROPANOIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP2017128528
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing an (S)-2-hydroxypropanoic acid derivative and ambrisentan having high optical purity in an industrially advantageous manner.SOLUTION: There is provided a method for producing an (S)-2-hydroxypropanoic acid derivative represented by the formula (1a) by reacting an (RS)-2-hydroxypropanoic acid derivative represented by the formula (1) with (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine to form a diastereomer salt, followed by desalting.SELECTED DRAWING: None
Inventors:
AMAGASA KATSUAKI
ONAMI TOSHIHIKO
ONAMI TOSHIHIKO
Application Number:
JP2016008387A
Publication Date:
July 27, 2017
Filing Date:
January 20, 2016
Export Citation:
Assignee:
TOA EIYO LTD
International Classes:
C07C51/50; A61P9/12; A61P11/00; C07B57/00; C07C59/64; C07D239/34
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
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