Title:
硫酸化多糖の製造方法及びＰＡＰＳの製造方法
Document Type and Number:
Japanese Patent JP7398684
Kind Code:
B2
Abstract:
The invention provides a method for producing sulfated polysaccharides by reacting a PAPS production/regeneration system utilizing the metabolic activity of a microorganism or a treated matter thereof with a microorganism expressing a sulfation enzyme or a treated matter or extract thereof upon mixing of inexpensive raw materials such as magnesium sulfate. The invention also provides a method for producing PAPS from inexpensive raw materials. The methods involve preparing a transformant (a) of a bacterium of the genus Corynebacterium, which contains a gene encoding an ATP sulfurylase and a gene encoding an APS kinase, which are expressible, and in which a cell plasma membrane of the transformant (a) is substance-permeable, or a treated matter of the transformant (a), and conducting a reaction for producing PAPS by using a reaction solution containing ATP or an ATP source, a sulfate ion source, and the transformant (a) or the treated matter thereof.
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Inventors:
Kenta Fukunaga
Akira Nishihara
Ryosuke Kato
Masahiro Kurato
Mikio Hayashi
Shinichi Hashimoto
Akira Nishihara
Ryosuke Kato
Masahiro Kurato
Mikio Hayashi
Shinichi Hashimoto
Application Number:
JP2022560338A
Publication Date:
December 15, 2023
Filing Date:
April 02, 2021
Export Citation:
Assignee:
Renselair Polytechnic Institute
OTSUKA PHARMACEUTICAL FACTORY,INC.
Kirin Biomaterials Co., Ltd.
OTSUKA PHARMACEUTICAL FACTORY,INC.
Kirin Biomaterials Co., Ltd.
International Classes:
C12P19/32; C12P19/04
Domestic Patent References:
| JP2002530087A | ||||
| JP2017520267A | ||||
| JP2014525244A | ||||
| JP2013501519A |
Attorney, Agent or Firm:
Patent Attorney Corporation Eiko Office