Title:
METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS
Document Type and Number:
Japanese Patent JP2018002698
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing trifluoromethyl group-containing alcohols useful as synthetic intermediates for medicines and agrochemicals.SOLUTION: This invention relates to a method for producing trifluoromethyl group-containing alcohols expressed by a formula (2), comprising: making carbonyl compounds expressed by a formula (1) react with trifluoromethane in an organic solvent in the presence of polyvalent ethers and potassium tert-butoxide, or kalium hexamethyldisilazide. (Rand Rare each independently a phenyl group etc.; Rmay combine with R, to form a ring, and both R1 and R2 are not hydrogen atoms).SELECTED DRAWING: None
Inventors:
SHIBATA TETSUO
SAITO TAKUYA
KAGAWA TAKUMI
SAITO TAKUYA
KAGAWA TAKUMI
Application Number:
JP2016212014A
Publication Date:
January 11, 2018
Filing Date:
October 28, 2016
Export Citation:
Assignee:
NAGOYA INST TECH
TOSOH F TECH INC
TOSOH F TECH INC
International Classes:
C07C29/38; C07B41/02; C07C33/46; C07C33/48; C07C35/52; C07C41/30; C07C43/23; C07C201/12; C07C205/26; C07C213/00; C07C215/68; C07D213/30; C07D307/42; C07D333/16
Domestic Patent References:
| JP2014519486A | 2014-08-14 |
Other References:
品田英泰ET AL.: "トリフルオロメタンを用いた含フッ素有機化合物の合成研究", 日本大学生産工学部学術講演会講演概要, vol. 46th, ROMBUN No.4-32, JPN6020018293, 2013, ISSN: 0004331915
PRAKASH, G. K. SURYA ET AL.: "Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers", SCIENCE, vol. 338, JPN6020031507, 2012, pages 1324 - 1327, XP055514663, ISSN: 0004331916, DOI: 10.1126/science.1227859
RUSSELL JAMIE ET AL.: "Effective Nucleophilic Trifluoromethylation with Fluoroform and Common Base.", TETRAHEDERON, vol. 54, JPN6020031506, 1998, pages 13771 - 13782, ISSN: 0004331917
PRAKASH, G. K. SURYA ET AL.: "Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers", SCIENCE, vol. 338, JPN6020031507, 2012, pages 1324 - 1327, XP055514663, ISSN: 0004331916, DOI: 10.1126/science.1227859
RUSSELL JAMIE ET AL.: "Effective Nucleophilic Trifluoromethylation with Fluoroform and Common Base.", TETRAHEDERON, vol. 54, JPN6020031506, 1998, pages 13771 - 13782, ISSN: 0004331917
Attorney, Agent or Firm:
Norio Hagi