METHOD FOR PROMOTING ANGIOGENESIS, VASCULARIZATION, OR VESSEL REPAIR OR FOR INHIBITING TUMOR ANGIOGENESIS

Japanese Patent JP2014196317

A

PROBLEM TO BE SOLVED: To provide: a novel treatment method for improving a function of endothelial cells and neovascularization; and a pharmaceutical composition having anti-angiogenic activity.SOLUTION: A method for influencing miR-92 expression in a cell is provided which comprises (a) a step of preparing a cell; and (b1) a step of reducing the miR-92 expression in the cell in order to promote vascularization or vessel repair by introducing an antisense molecule against the miR-92 into the cell, or (b2) a step of increasing miR-92 expression in the cell in order to inhibit tumor angiogenesis by introducing, into the cell, a construct including an expressible miR-92 sequence. The pharmaceutical composition is also provided which contains an agent for reducing miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing miR-92 expression in a cell in the form of a construct for expressing miR-92.

STEFANIE DIMMELER
ANDREAS M ZEIHER
ANGELIKA BONAUER
CARMEN URBICH

JP2014116545A

October 16, 2014

June 05, 2014

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T2CURE GMBH

A61K48/00; A61K31/7105; A61P9/00; A61P9/10; A61P35/00; C12N15/09; C12N15/113

WO2006133022A2

2006-12-14

JPN6014034651; ＣＩＲＣＵＬＡＴＩＯＮ ＶＯＬ．１１８，　ＮＯ．１８，　ＳＵＰＰＬ．, 20081028, ＡＢＳＴＲＡＣＴ　５４４３
JPN6013022195; ＣＩＲＣＵＬＡＴＩＯＮ ＶＯＬ．１１６，　ＮＯ．１６，　ＳＵＰＰＬ．, 20071016, ＡＢＳＴＲＵＣＴ　８９６
JPN6015027803; ＳＣＩＥＮＣＥ ＶＯＬ．３１７, 20070727, Ｐ．４６１-４６２

Takashi Shoji

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