Title:
変性サポニンによる薬物送達促進方法
Document Type and Number:
Japanese Patent JP3684370
Kind Code:
B2
Abstract:
Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceutical compositions for enhancing the transport of pharmacologically active substances across mucous membranes of an animal. Also disclosed are modified saponins having reduced irritability wherein the aldehyde group is reduced and the fatty acid moiety may be removed by hydrolysis. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.
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Inventors:
Kencil, Charlotte A.
Sorticik, the scene
Marsani, Dante Jay
Sorticik, the scene
Marsani, Dante Jay
Application Number:
JP50560193A
Publication Date:
August 17, 2005
Filing Date:
July 01, 1993
Export Citation:
Assignee:
ANTIGENICS INC.
International Classes:
A61K9/00; A61K31/70; A61K38/28; A61K39/39; A61K47/28; A61K47/36; C07J53/00; C07J63/00; (IPC1-7): A61K47/36; A61K9/00; C07J53/00
Domestic Patent References:
| JP5764610A | ||||
| JP6245595A | ||||
| JP62207226A |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga